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Beilstein J. Org. Chem. 2013, 9, 966–973, doi:10.3762/bjoc.9.111
Graphical Abstract
Figure 1: Structures of lead Rho/MKL1/SRF inhibitor 1 and conformationally restricted analogue 2.
Figure 2: Strategy for tag-free photolabeling in whole cells (PG = photoactivatable group, TAG = fluorescent ...
Scheme 1: General synthesis of model benzophenone probes.
Scheme 2: Synthesis of aryl azide model probe 14.
Scheme 3: Synthesis of benzophenone photoaffinity probe 19.
Scheme 4: Synthesis of benzophenone photoaffinity probe 24.
Scheme 5: Synthesis of aryl azide photoaffinity probes.
Figure 3: Photoprobe 24 (CCG-206559) retains biological activity to block prostate cancer migration. A. Cellu...
Figure 4: Structure of the competitor used in the photolabeling experiment.
Figure 5: SDS-PAGE gel of photolabeling experiment in whole PC-3 cells. Lane 1 contains 0.3 µM 24 after 30 mi...